date:Aug 05, 2014
eficiency and in a range of human and mouse cell lines with impaired mitochondrial function.
Dr. Thorburn commented, Mitochondrial energy generation disorders are serious conditions that vary widely in their clinical features and genetic basis. Our mouse models of Complex I deficiency show an imbalance in the NAD+/NADH ratio and NR has been shown to boost NAD levels in various model systems. We are excited to be able to study NR in a range of different pre-clinical model systems to investigate