date:May 11, 2012
ly the isoquinolinic alkaloids and acetogenins, structurally homogenous fatty acid derivatives known as polyketides specific to Annonaceae.
This class of polyketides are among the most potent inhibitors of complex I of the mitochondrial respiratory chain known in nature, some 50-fold more potent than the class complex I inhibitor MPP + and two times more potent than rotenone in inducing neuronal death.
Epidemiological evidence
The significance of these findings relates to the abnormally hi