date:May 11, 2012
queous extract of leaves and the extract of the root bark of Annona muricata and infusions and decoctions of the fruit have been shown in both in vitro and in vivo experiments to be a potentially toxic inhibitor of the mitochondrial respiratory chain.
Experimental studies have confirmed annonacin, an isoquinoline derivative, the major acetogenin found in soursop, as the toxic agent responsible for this effect. A. muricata and other plants of Annonaceae contain potential neurotoxins, particular